Respuesta :
Answer:
- multiple pathways
- ligands/signaling molecules
- inorganic phosphate
- inactive relay proteins
Explanation:
Receptor Tyrosine Kinase:
- Receptor tyrosine kinase (RTK) is the largest class of enzyme linked cell surface receptors.
- When a growth factor or a ligand binds to two neighboring RTK receptors, the two receptors bind together and form a dimer.
- This change in the conformation of the RTKs activates the associated tyrosine kinase enzymes.
- Tyrosine kinases break down ATP to ADP and phosphorylate the RTKs. Cross phosphorylation between the receptors helps activate multiple tyrosine kinases on the neighboring RTK.
- Once phosphorylated, the cytoplasmic ends of the RTKs are available for docking by relay proteins or signaling molecules with an SH-2 domain.