Which of the following modifications of the DNA would produce the greatest change in the primary structure of the polypeptide chain?
a. Deleting the first T in the second triplet
b. Changing the second triplet to read 3' CTC 5'
c. Changing the third triplet to read 3' AAC 5'
d. Changing the fourth triplet to read 3' CCA 5'
e. Deleting the sixth triplet